I was thinking about people who are panicking these days. Many of them were used to have a strong control over their lives and now they are facing unpredictability, invisible enemy and lack of control of their future. In reality, nothing in our lives is permanent and predictable and we never know when the change comes.
Usually we become acutely aware of impermanence only when it happens and turns our lives upside down, classically at the time of old age, sickness and death. Nothing lasts forever, we are in constant flow of changes from a moment to another. Seeming predictability of our lives lasted for a while, then it was gone, replaced with unpredictability of the pandemic, but one day this will be gone, too. Often fears are stronger when we focus only on what we have in front of our nose and forget about the larger perspective, including constant chances and impermanence.
Impermanence and uncertainty about our external conditions are neither positive nor negative on their own, they are what me make of it. To a spiritually inclined person this helps us to turn inside and spend more time training our mind (Tib. བྐྱོ་སྐྱོང་), developing loving compassion and other virtuous mental states. Our mind can be trained, just like our bodies can be trained. which helps us to maintain a positive mental attitude and make our life meaningful regardless the circumstances.
Awareness of impermanence in the time of difficulties can be a beacon of hope, and awareness of impermanence in any time, happy or sad, can be a source of a profound sense of purpose beyond this life.